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KMID : 0931320170170040175
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대한상부위장관.헬리코박터학회지
2017 Volume.17 No. 4 p.175 ~ p.178
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Chemoprevention of Gastric Cancer: Statins
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Choi Sang-Hyeon
Baik Gwang-Ho
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Abstract
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Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Because the gastric cancer-related mortality rate is expected to increase, chemo-preventive strategies for gastric cancer are required. Statins inhibit 3-hydroxy-3 methylglutaryl coenzyme A reductase, the enzyme involved in the rate-limiting step in cholesterol synthesis. Several studies have shown that statins have potential protective effects against gastric cancer; however, other studies have reported contradictory results. Therefore, further studies are needed to clarify the role of statins in the chemoprevention of gastric cancer.
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KEYWORD
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Chemoprevention, Hydroxymethylglutaryl-CoA reductase inhibitors, Stomach neoplasms
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